Recently funded awards

This page lists the investigator-led programmes, projects and fellowships that we have recently supported through our response-mode grant funding schemes.

Select a funding committee to see what they have funded to date in 2022 (for Grant Award Letters issued up to November 2022):
 

November 2022

Clinical Trial Awards

Professor Simon Bailey, Newcastle University

YCMB-LR: Prospective international SIOPE/CONNECT phase-III trial to improve neurocognitive outcomes in young children with low-risk medulloblastoma

Dr Toby Eyre, Oxford University Hospitals NHS Foundation Trust

ZEBRA - Zanubrutinib plus rituximab (Zanu -R) as fixed duration, early intervention versus observation for patients with indolent mantle cell lymphoma: a randomised phase II clinical trial

Biomarker Project Awards

Professor Timothy Aitman & Professor Duncan McLaren, University of Edinburgh

Investigating the potential of cell-free DNA biomarkers to personalise radiotherapy for prostate cancer

Prospective Sample Collection Awards

Dr Jon Griffin & Professor James Catto, University of Sheffield

Novel markers of response to neoadjuvant chemotherapy in urothelial carcinoma in the GUSTO clinical trial

Dr Kwee Yong, University College London

Understanding tumour resistance and relapse in the RADAR study

Professor Jean Abraham, University of Cambridge

PARTNER Sample Collection (Costed Extension)

 

June 2022

Clinical Trial Awards

Dr Mark Gaze, University College London    
LuDO-N: A dose intense phase II trial of 177-Lutettium DOTATATE molecular radiotherapy in children with primary refractory or relapsed high-risk neuroblastoma

Professor Maria Hawkins and Dr Ganesh Radhakrishna, University College London

CRUK/22/011: PROTIEUS - Proton Beam Therapy and adjuvant Immunotherapy in Oesophageal cancer

November 2022

​​Programme Awards

New Programmes

Professor Paul Klenerman & Dr Benjamin Fairfax, University of Oxford

Defining the role of MAIT cells in Cancer Immunotherapy

Dr Philip Zegerman, University of Cambridge

Targeting DNA replication control for novel cancer therapy strategies

Renewing Programmes

Professor Laura Machesky, University of Cambridge

Mechanosensing, cytoskeletal control and metabolic demand: how tumour growth and metastasis is fuelled by the microenvironment

Professor Derek Mann & Professor Owen Sansom, Newcastle University

Reprogramming neutrophils to reinvigorate the immunosuppressed HCC microenvironment

Professor Brian Huntly, University of Cambridge 

The role of mutational synergy and oncogenic signalling to chromatin in initiation, maintenance and disease resistance in Acute Myeloid Leukaemia (AML)

Professor Kevin Harrington, Institute of Cancer Research

Strategies for optimised adjuvant immunotherapy following curative-intent radiotherapy or chemoradiotherapy for squamous cell cancer of the head and neck

Professor Steve Clifford, Newcastle University

Biomarker-driven individualisation of medulloblastoma therapy

Professor Karim Labib, University of Dundee

Regulation of metazoan replisome disassembly at stalled replication forks and during mitosis

Programme Foundation Awards

Dr Laura Greaves, Newcastle University

Determining and targeting metabolic vulnerabilities in colorectal cancer

Multidisciplinary Project Awards

Professor Nancy Papalopulu, Professor Robert Clarke & Professor Magnus Rattray, University of Manchester

A dynamical systems approach to understand plasticity and non-genetic heterogeneity in cancer

Dr Benjamin Schumann, Dr Ilaria Malanchi & Dr Paul Huang, Imperial College London

Glycosyltransferase engineering to probe the biology of O-linked protein glycosylation in metastatic breast cancer

 

June 2022

​​Programme Awards

New Programmes

Professor Simon Leedham, University of Oxford
Stem cells and adaptive molecular phenotype in colorectal cancer (STAMP-CRC)

Professor Stephen Tait, University of Glasgow
Understanding and targeting cell death oncogenicity

Professor Gareth Thomas & Dr Christopher Hanley, University of Southampton
Understanding cancer-associated fibroblast phenotype and function in head & neck cancer: targeting strategies to overcome immunotherapy resistance

Professor John Wood & Dr Shafaq Sikandar, University College London
Targeting Cancer Pain

Professor Marion MacFarlane & Professor Daniel Murphy, MRC Toxicology Unit

REMIT: Reconstructing the In Vivo Evolution of Mesothelioma for Improved Therapy

Renewing Programmes

Professor David Barford, University of Cambridge
Molecular and cellular structural studies of chromosome segregation

Programme Foundation Awards

Dr Marco Gerlinger, Queen Mary, University of London
Improving immunotherapy efficacy and defining the tumour antigen landscape that is recognised by CD8 T-cells in microsatellite stable colorectal cancer

Dr Matthew Hoare, University of Cambridge
Recurrent somatic mutations in the cancerisation field effect of chronic liver disease

Multidisciplinary Project Awards

Dr Hugh Robinson & Dr Kevin O’Holleran, University of Cambridge
Revealing calcium channel function in neuroendocrine cancers by integrating electrophysiology and 3D super-resolution microscopy

Cancer Immunology Project Awards

Dr Leonie Unterholzner, Lancaster University
STING signalling as link between DNA damaging therapies and innate immunity in bladder cancer

November 2022

Programme Awards

Professor Caroline Dive & Dr Phil Crosbie, University of Manchester
Development of a multi-modal liquid biopsy for the early detection of lung cancer

Professor Clare Turnbull, Institute of Cancer Research, Dr David Adams, Wellcome Sanger Institute, and Dr Greg Findlay, The Francis Crick Institute
Defining the compendium of pathogenic germline alleles in cancer susceptibility genes via multiplex assays of variant effect (CG-MAVE)

Project Awards

Dr Jacqueline Shields, King's College London
Exploiting The Lymphatic System For Early Detection And Risk Stratification Biomarkers

Dr James Reading, Professor Sam Janes & Dr Maxine Tran, University College London
A multiomic T cell differentiation index (TEDI) for non-invasive early detection of lung and renal cancer

Primer Awards

Dr Gwen Murphy, Imperial College London
Serologic biomarkers of stomach cancer precursor lesions

Dr James Yarmolinsky, University of Bristol
Using reverse Mendelian randomization to discover novel circulating biomarkers for early detection of cancer

Dr Emma Woodward, University of Manchester
ATLAS - eArly deTection in Li frAumeni Syndrome

Professor Paula Mendes, University of Birmingham
Using superselective glycan-binding nanoparticles to create a clinical assay for early ovarian cancer detection

Dr Patrick Kierkegaard, Imperial College London
Developing an equity-focused Target Product Profile for non-invasive biomarker tests tailored to support mobile testing outreach programmes to reduce cancer inequalities

 

May 2022

Programme Awards

Professor Fiona Walter, Queen Mary, University of London, & Professor Stephen Pereira, University College London
CANDETECT: Accelerating detection of upper gastro-intestinal (UGI) cancers using a multi- cancer early detection platform in primary care

Project Awards

Professor Sam Janes, Dr Amy Webster and Professor Christina Thirlwell, University College London    
Epi-ASCENT: The epigenetic landscape of screen-detected lung cancers

Dr Rasha Abu-Eid, University of Aberdeen 
Integrating Raman spectroscopy and digital pathology as a novel tool for objective grading of oral epithelial dysplasia

Dr Floor Christie-de Jong, University of Sunderland, & Professor Katie Robb, University of Glasgow
Improving uptake of breast, bowel and cervical cancer screening among Muslim women: a feasibility study of a peer-led, faith-based intervention

Primer Awards

Dr Richard Hopkinson, University of Leicester
Detection of aldehyde cancer biomarkers by harnassing their carcinogenic reactivity

Dr Alexander Oldroyd, University of Manchester   
The MyoScreen Study - Investigating the Utility of Liquid Biopsy as a Method of Early Detection of Idiopathic Inflammatory Myopathy-Associated Cancer

Dr Francesco Boccellato, University of Oxford    
Early detection of gastric cancer by the identification of functional markers driving pre- malignant alterations of the tissue

Dr Lauren Ford, Imperial College London  
IntelligentToilet

Dr James Flanagan, Imperial College London 
Combining diet and symptom management for earlier detection of cancer using transactional data

Dr Samantha Hiu Yan Ip, University of Cambridge    
Investigating transportability of cancer detection models across datasets and time using population-wide electronic health data    

Dr Jennifer Heaney, University of Birmingham  
Improving myeloma diagnosis using a simple rapid test

Dr Denitza Williams, Cardiff University  
Novel decision support intervention to support choice in cervical screening modality

Dr Qiang Wang, University of Edinburgh 
Towards in-vivo in-situ early lung cancer detection using fluorescence lifetime imaging endomicroscopy: a preliminary study on data-driven characterisation of lung cancer using label-free autofluorescence lifetime images on unstained lung cancer tissue

Dr Sarah Haywood-Small, Sheffield Hallam University
Vocs-box breathomics: early detection and diagnosis of mesothelioma

Dr Leonid Nikitenko, University of Hull    
EARLY DIAPAC: EARLY DIAgnosis of PAncreatic Cancer by combined proteomics and genomics testing of pancreatic cyst fluid
    
Dr Christopher Rowlands, Imperial College London 
Cancer Led Optical Ultrasound Detection    

Dr Christian von Wagner, University College London   
Development and evaluation of a chatbot to support informed choice in the UK Bowel Cancer Screening Programmes

Professor Ferdia Gallagher, University of Cambridge  
Early detection of structural and metabolic changes in small renal masses using advanced MRI to differentiate benign from malignant lesions

Dr Ardhendu Behera, Edge Hill University 
LungHealth AI: Using AI to improve early detection and diagnosis of lung cancer

November 2022

Programme Award

Renewing Programme

Professor Amanda Cross, Imperial College London
Screening, Prevention and Diagnosis of Gastrointestinal Cancer

Project Awards

Professor Chris Cardwell, Queen's University Belfast
Antibiotic use and survival from breast cancer

Dr Jamie Hartmann Boyce & Dr Nicola Lindson, University of Oxford
Synthesising evidence on e-cigarettes: two living systematic reviews exploring their efficacy and safety for smoking cessation, and how to stop using them

Dr Tom Dudding & Dr Barry Main, University of Bristol
Head and neck 5000 – Identifying factors affecting survival and secondary physical effects of treatment at 10 years

Dr Laura Woods, Newcastle University
Developing a screening engagement index (SEI) for England

Dr Toral Gathani, University of Oxford
The Associations of Ethnicity and Breast Cancer

 

May 2022

Programme Awards

New Programme

Professor Claudia Allemani and Professor Michel Coleman, London School of Hygiene and Tropical Medicine
Global surveillance of cancer survival (CONCORD-4): 20-year trends in survival from 22 adult cancers and all childhood cancers, for patients diagnosed during 2000-2019 or later

Project Awards

Dr Simon Lord and Professor Sarah Blagden, University of Oxford
Exploring metformin’s mechanisms of action in mTP53-driven cancers

Professor Shahid Khan and Professor Simon Rushbrook, Imperial College London
Asp-PSC: Effect of Aspirin on Reducing Cancer in Primary Sclerosing Cholangitis

Dr Crawford Moodie, University of Stirling
The Adult Tobacco Policy Survey: Understanding how smokers and ex-smokers respond to tobacco control policies in the UK

Professor Nicholas Timpson and Dr Vanessa Tan, University of Bristol
Role of directly measured metabolic profile as an intermediate between adiposity and endometrial cancer: triangulation of evidence from independent sources

November 2022

Career Establishment Award

Dr Barrie Peck, Queen Mary, University of London
Understanding and exploiting Acetyl-CoA metabolism in Small Cell Lung Cancer

Senior Cancer Research Fellowship

Dr Jörg Mansfeld, Institute of Cancer Research
Discovery and functional investigation of how ROS can regulate the cell cycle

Clinician Scientist Fellowship

Dr Ayesha Noorani, Wellcome Sanger Institute 
Mapping the clonal dynamics and somatic mutations of the human oesophagus during disease, development and carcinogenesis

Dr Sung Pil Hong, Imperial College London
Single-cell multi-omic profiling of intratumoral heterogeneity to tackle oesophageal cancer cell adaptation to chemotherapy

Dr Gurdeep Mannu, University of Oxford
Pre-invasive and Invasive breast cancer: from risk factors to optimal treatment

 

May 2022

Career Establishment Award

Dr Manavendra Pathania, University of Cambridge 
The role of partner mutations in histone-mutant paediatric glioma

Dr Oscar Rueda, University of Cambridge
A statistical dynamic system for breast cancer prognosis and patient monitoring

Senior Cancer Research Fellowship

Dr Sophie Acton, University College London
Harnessing the lymphoid tissue niche to boost anti-tumour immunity 

Clinician Scientist Fellowship

Dr Ehsan Ghorani, Imperial College London 
Deciphering mechanisms of immune dysfunction and immunotherapy sensitivity in gestational trophoblastic neoplasia 

Advanced Clinician Scientist Fellowship

Dr Jyoti Nangalia, Wellcome Sanger Institute
Deciphering timelines and trajectories to blood cancer 

More facts and figures about our research funding

Facts and figures about our research funding

Find out more about how and where we supported research in the last year with our interactive map and infographics.

Funding committees

Successful applicant case studies

Find out how our current grantees successfully applied for funding.

Read more

Awards funded in FY2021-2022

See list of awards funded in FY2021-2022